ABSTRACT
Statins are a kind of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors, which are commonly used to reduce cholesterol level, and prevent cardiovascular and cerebrovascular diseases. In recent years, more and more researches have showed that statins could inhibit angiogenesis through inhibiting the proliferation, invasion and metastasis of cancer cells, and could promote cancer cells apoptosis and synergetically enhance the effect of radiotherapy and chemotherapy to play a potential anti-tumor role. This paper reviews the domestic and foreign research progresses of the anti-tumor mechanisms of statins.
ABSTRACT
Vimentin, a kind of type Ⅲ intermediate filament protein, is the major component of cytoskeleton of stromal cells. Increasing researches have demonstrated that vimentin is over-expressed in muiltple tumor tissues, and is closely related with the occurrence, development, invasion and metastasis of tumors. However, correlated studies including cervical neoplasm, endometrial neoplasm and ovarian neoplasm start comparatively late with inconsistent conclusions, thus, a lot of mechanisms need to be further investigated. This paper reviews the expressions and the clinical significances of vimentin in 3 kinds of gynecological malignant tumors.
ABSTRACT
Objective To investigate the association of interferon (IFN) γ gene polymorphisms and risk and prognosis of HPV cervical infection.Methods PCR-ASP was used for detectiug IFN-γ rs2430561 polymorphism in 179 HPV positive patients and 328 HPV negative normal controls.Results The frequency of A allele of 63.7％ (228/358) was significantly higher than the frequency of T allele of 36.3％ (130/358) in HPV positive group (P =0.045).The frequencies were 41.3％ (74/179) in AA genotype and 14.0％ (25/179) in TT genotype,women carrying AA genotype increased the risk of HPV infection compare with those with TT genotype (OR =1.784,95％ CI:1.031-3.088,P =0.039).During follow-up,the rate of HPV positive again in AA genotype was 83.8％ (62/74),while TT genotype was 20.0％ (5/25).In the analysis of Kaplan-Meier,the cumulative HPV negative rates of AA,TA and TT genotype exhibited significantly different (P =0.008).The cumulative HPV negative rate of AA genotype was the lowest (1.1％-5.9％).Conclusions IFN-γ rs2430561 polymorphisms confer the susceptibility to HPV infection.Women with AA genotype exhibited higher risk of infection and inclined to be continuous status and recurrence after HPV infection.
ABSTRACT
Gastrointestinal stromal tumor (GIST) represents the most common intramural mesenchymal tumor of the gastrointestinal tract, but the synchronous occurrence of GIST in the stomach and gynecological cancer is rare. We present a unique case of a 56-year-old female patient who was diagnosed with the synchronous development of GIST and an isolated parenchymal splenic metastasis of ovarian cancer. She underwent a wide local excision of gastric lesions with splenectomy. A morphological (histological and immunohistochemical) study established a spindle-cell type of gastrointestinal tumor that expressed CD117, and a parenchymal recurrence of ovarian papillary serous adenocarcinoma. The patient has remained alive and disease-free for 30 months since the last operation. A small GIST concomitant with an isolated parenchymal splenic metastasis of ovarian cancer is rarely encountered. The coexistence of GIST with other malignancies constitutes an intriguing oncologic model. Surgeons are advised to be alert against possible primary GIST accompanying other neoplasms.